Not with Skype version 8.60 (May 2020) and later.

Skype does not allow the possibility to load any 3rd party virtual driver, which includes the wireless A/V driver of Huddle Hub.

Workaround 1 (launch Skype version 8.59)

Download Skype 8.59 from here:

Make sure to double-click the Skype icon to open it, without drag-and-dropping it to the App folder. This will prevent automatic updates to the new version.

Workaround 2 (remove code signature from Skype)

Proceed as follows:

- close Skype

- open the system Terminal (App -> Utilities)

- paste the following instruction in the Terminal and execute it:

codesign --remove-signature "/Applications/ Helper (Renderer).app"

- open Skype